Study: Nalls, 2014

Population Ethnicity Diagnosis Source # Cases (% women) # Controls (% women) AAO (sd) AAO range AAE (sd) AAE range Ctrl age (sd) Ctrl age range # Polymorphisms
USA (PROGENI-GenePD) C UKPDSBB CL 828 (40%) 852 (60%) 62 (11) - - - 55 (13) - 9,762

Polymorphisms in this population [-]

Polymorphism Location (hg19) Gene Allele contrast Ethnicity # Studies # Samples 1000G CEU 1000G CHB+JPT Meta OR (95%CI) I2 (95%CI) Meta P-value
rs11867635 chr17:43892021 CRHR1 A vs. G All: C 14 103,235 0.142 (A) - 1.10 (1.05-1.16) 0 (0-25) 3.06e-05
rs242941 chr17:43892520 CRHR1 A vs. C All: C 14 103,235 0.292 (A) 0.125 (A) 1.11 (1.07-1.14) 0 (0-35) 6.19e-09
rs242940 chr17:43892600 CRHR1 A vs. G All: C 14 103,235 0.492 (A) 0.125 (A) 0.92 (0.90-0.95) 8 (0-46) 1.03e-06
rs55915917 chr17:43892784 CRHR1 G vs. T All: C 11 31,551 0.208 (G) - 0.49 (0.43-0.56) 0 (0-50) 5.12e-24
rs55668363 chr17:43892788 CRHR1 A vs. G All: C 11 31,551 0.208 (A) - 0.49 (0.43-0.56) 0 (0-50) 5.05e-24
rs171440 chr17:43893487 CRHR1 A vs. G All: C 14 103,235 0.492 (A) 0.142 (G) 1.08 (1.05-1.12) 9 (0-46) 1.20e-06
rs173365 chr17:43901074 CRHR1 A vs. G All: C 14 103,235 0.383 (A) 0.117 (A) 0.89 (0.86-0.92) 5 (0-57) 1.59e-12
rs17763104 chr17:43905795 CRHR1 A vs. G All: C 14 103,235 0.15 (A) - 1.10 (1.05-1.15) 0 (0-21) 6.69e-05
rs242951 chr17:43909412 CRHR1 C vs. T All: C 14 103,235 0.375 (C) - 0.89 (0.86-0.92) 7 (0-58) 8.72e-13
rs17689966 chr17:43910455 CRHR1 G vs. A All: C 14 103,235 0.392 (G) 0.208 (G) 0.89 (0.86-0.92) 6 (0-58) 8.01e-13
rs242949 chr17:43911716 CRHR1 T vs. G All: C 14 103,235 0.458 (T) 0.208 (G) 1.08 (1.05-1.12) 13 (0-52) 3.20e-06
rs242947 chr17:43917136 CRHR1 [+3942bp] G vs. A All: C 14 103,235 0.392 (G) 0.208 (G) 0.89 (0.86-0.92) 5 (0-57) 2.31e-13
rs242944 chr17:43923180 SPPL2C G vs. A All: C 14 103,235 0.342 (G) 0.225 (G) 0.89 (0.86-0.92) 8 (0-46) 6.88e-13
rs8064870 chr17:43926789 SPPL2C [+2351bp] C vs. T All: C 14 103,235 0.483 (C) 0.208 (C) 0.91 (0.88-0.94) 14 (0-53) 5.47e-09
rs8068916 chr17:43926987 SPPL2C [+2549bp] G vs. T All: C 14 103,235 0.475 (G) 0.208 (G) 0.91 (0.88-0.94) 14 (0-52) 6.92e-09
rs17690883 chr17:43928866 SPPL2C [+4428bp] T vs. C All: C 14 103,235 0.142 (T) 0.042 (T) 1.10 (1.05-1.15) 0 (0-46) 1.33e-04
rs7221167 chr17:43933307 SPPL2C [+8869bp] C vs. T All: C 14 103,235 0.475 (C) 0.167 (C) 0.83 (0.80-0.86) 44 (0-70) 1.08e-23
rs9913081 chr17:43933802 SPPL2C [+9364bp] G vs. T All: C 14 103,235 - - 1.39 (1.30-1.48) 5 (0-57) 3.56e-22
rs2316770 chr17:43934256 SPPL2C [+9818bp] A vs. G All: C 14 103,235 0.442 (A) 0.175 (A) 1.08 (1.04-1.11) 0 (0-49) 3.71e-05
rs962885 chr17:43935631 SPPL2C [+11193bp] T vs. C All: C 14 103,235 0.342 (T) 0.192 (C) 1.14 (1.10-1.18) 48 (4-72) 6.75e-13
rs2301689 chr17:43935838 SPPL2C [+11400bp] T vs. C All: C 14 103,235 0.333 (T) 0.217 (C) 1.14 (1.10-1.18) 48 (4-72) 4.38e-13
rs242935 chr17:43936410 SPPL2C [+11972bp] C vs. T All: C 14 103,235 - - 0.88 (0.85-0.91) 46 (0-71) 4.76e-12
rs242932 chr17:43939136 SPPL2C [+14698bp] T vs. A All: C 14 103,235 0.333 (T) 0.192 (A) 1.13 (1.09-1.17) 45 (0-71) 3.85e-12
rs242931 chr17:43939225 SPPL2C [+14787bp] A vs. G All: C 14 103,235 0.333 (A) 0.192 (G) 1.13 (1.09-1.17) 45 (0-70) 5.81e-12
rs242928 chr17:43943051 SPPL2C [+18613bp] A vs. G All: C 14 103,235 0.45 (A) 0.208 (A) 1.07 (1.03-1.10) 0 (0-50) 9.52e-05
rs11869096 chr17:43945100 SPPL2C [+20662bp] A vs. G All: C 14 103,235 0.45 (A) 0.217 (A) 1.07 (1.03-1.10) 0 (0-51) 1.12e-04
rs242922 chr17:43946370 SPPL2C [+21932bp] A vs. C All: C 14 103,235 0.333 (A) 0.383 (C) 1.15 (1.11-1.19) 28 (0-62) 1.55e-15
rs1560312 chr17:43978988 MAPT G vs. A All: C 14 103,235 0.275 (G) - 0.86 (0.83-0.89) 24 (0-60) 3.37e-17
rs3785879 chr17:43985636 MAPT A vs. C All: C 14 103,235 0.425 (A) 0.375 (A) 1.09 (1.05-1.12) 0 (0-24) 1.03e-06
rs62056850 chr17:43992581 MAPT T vs. C All: C 14 103,235 0.208 (T) - 0.77 (0.74-0.80) 0 (0-45) 6.81e-37
rs3785880 chr17:43993376 MAPT G vs. T All: C 14 103,235 0.45 (G) 0.367 (G) 1.09 (1.05-1.12) 0 (0-18) 1.12e-06
rs17649553 chr17:43994648 MAPT T vs. C All: C 20 114,483 0.217 (T) - 0.77 (0.75-0.80) 0 (0-37) 6.11e-49
rs8080903 chr17:43996140 MAPT T vs. C All: C 14 103,235 0.392 (T) 0.225 (C) 1.12 (1.09-1.16) 39 (0-68) 2.39e-12
rs1560313 chr17:43996561 MAPT A vs. G All: C 14 103,235 0.392 (A) 0.208 (G) 1.12 (1.09-1.16) 39 (0-68) 3.28e-12
rs9904290 chr17:44002271 MAPT A vs. G All: C 14 103,235 0.392 (A) 0.242 (G) 1.12 (1.09-1.16) 38 (0-67) 6.24e-12
rs1001945 chr17:44005821 MAPT C vs. G All: C 14 103,235 0.4 (C) 0.242 (G) 1.12 (1.08-1.15) 36 (0-66) 1.83e-11
rs8078967 chr17:44008101 MAPT T vs. C All: C 14 103,235 0.383 (T) 0.242 (C) 1.12 (1.08-1.15) 35 (0-66) 2.30e-11
rs242557 chr17:44019712 MAPT A vs. G All: C 14 103,235 0.408 (A) 0.467 (A) 1.08 (1.04-1.12) 7 (0-58) 8.40e-06
rs62062775 chr17:44021960 MAPT A vs. G All: C 14 103,235 0.192 (A) - 1.12 (1.07-1.16) 27 (0-62) 4.08e-07
rs242562 chr17:44026739 MAPT A vs. G All: C 14 103,235 0.425 (A) 0.433 (G) 1.09 (1.05-1.12) 10 (0-48) 4.10e-06
rs878918 chr17:44031596 MAPT G vs. A All: C 14 103,235 0.283 (G) 0.15 (G) 1.11 (1.07-1.15) 45 (0-71) 1.26e-07
rs242554 chr17:44039365 MAPT C vs. T All: C 14 103,235 - - 0.90 (0.87-0.93) 14 (0-52) 4.70e-09
rs16940758 chr17:44040626 MAPT T vs. C All: C 14 103,235 0.192 (T) 0.108 (T) 1.10 (1.06-1.15) 21 (0-58) 8.99e-06
rs2664006 chr17:44041771 MAPT C vs. T All: C 14 103,235 - - 0.91 (0.88-0.94) 10 (0-48) 8.57e-09
rs62063286 chr17:44041987 MAPT T vs. C All: C 14 103,235 - - 0.92 (0.88-0.96) 17 (0-55) 6.04e-05
rs62063287 chr17:44041992 MAPT G vs. T All: C 14 103,235 - - 0.92 (0.88-0.96) 17 (0-55) 6.09e-05
rs76281607 chr17:44042782 MAPT C vs. T All: C 14 103,235 - - 0.91 (0.87-0.95) 21 (0-58) 1.04e-05
rs77169816 chr17:44042942 MAPT T vs. C All: C 14 103,235 0.183 (T) 0.175 (T) 1.10 (1.06-1.15) 17 (0-55) 7.19e-06
rs9896485 chr17:44050828 MAPT C vs. G All: C 14 103,235 0.317 (C) 0.392 (G) 1.10 (1.06-1.14) 7 (0-58) 1.53e-08
rs10514889 chr17:44051404 MAPT A vs. G All: C 14 103,235 0.317 (A) 0.475 (A) 1.10 (1.06-1.14) 7 (0-44) 1.98e-08