Study: Nalls, 2014

Population Ethnicity Diagnosis Source # Cases (% women) # Controls (% women) AAO (sd) AAO range AAE (sd) AAE range Ctrl age (sd) Ctrl age range # Polymorphisms
USA (IPDGC-NIA) C UKPDSBB CL 937 (40%) 1896 (53%) 58 (13) - - - 63 (10) - 9,622

Polymorphisms in this population [-]

Polymorphism Location (hg19) Gene Allele contrast Ethnicity # Studies # Samples 1000G CEU 1000G CHB+JPT Meta OR (95%CI) I2 (95%CI) Meta P-value
rs2968621 chr2:36160660 intergenic A vs. G All: C 15 108,990 0.417 (A) 0.35 (A) 0.93 (0.90-0.96) 0 (0-43) 1.13e-05
rs2968622 chr2:36161469 intergenic C vs. A All: C 15 108,990 0.408 (C) 0.35 (C) 0.93 (0.90-0.96) 0 (0-42) 9.26e-06
rs2949028 chr2:36161553 intergenic G vs. T All: C 15 108,990 0.408 (G) 0.342 (G) 0.93 (0.90-0.96) 0 (0-42) 1.17e-05
rs2949027 chr2:36162074 intergenic G vs. A All: C 15 108,990 0.417 (G) 0.317 (G) 0.93 (0.90-0.96) 0 (0-42) 1.16e-05
rs2949026 chr2:36162135 intergenic G vs. A All: C 15 108,990 0.417 (G) 0.325 (G) 0.93 (0.90-0.96) 0 (0-43) 1.25e-05
rs2968624 chr2:36162477 intergenic A vs. G All: C 15 108,990 0.458 (A) 0.433 (G) 0.93 (0.90-0.96) 0 (0-19) 2.75e-05
rs1880256 chr2:36162761 intergenic A vs. C All: C 15 108,990 0.417 (A) 0.325 (A) 0.93 (0.90-0.96) 0 (0-42) 1.19e-05
rs1404050 chr2:36164064 intergenic T vs. C All: C 15 108,990 0.433 (T) 0.325 (T) 0.94 (0.90-0.97) 0 (0-43) 7.18e-05
rs2949025 chr2:36164415 intergenic G vs. A All: C 15 108,990 0.433 (G) 0.317 (G) 0.94 (0.91-0.97) 0 (0-42) 8.50e-05
rs2949085 chr2:36164771 intergenic G vs. A All: C 15 108,990 0.433 (G) 0.317 (G) 0.94 (0.90-0.97) 0 (0-46) 9.09e-05
rs2949084 chr2:36165078 intergenic T vs. C All: C 15 108,990 0.433 (T) 0.317 (T) 0.94 (0.91-0.97) 0 (0-42) 7.49e-05
rs2949083 chr2:36165125 intergenic G vs. A All: C 15 108,990 0.433 (G) 0.317 (G) 0.94 (0.91-0.97) 0 (0-42) 7.47e-05
rs2949082 chr2:36165777 intergenic C vs. T All: C 15 108,990 0.442 (C) 0.442 (T) 0.94 (0.91-0.97) 0 (0-42) 7.63e-05
rs2968629 chr2:36170939 intergenic C vs. T All: C 15 108,990 0.475 (C) 0.325 (C) 0.94 (0.91-0.97) 0 (0-6) 1.36e-04
rs1357663 chr2:36172491 intergenic T vs. C All: C 15 108,990 0.433 (T) 0.317 (T) 0.94 (0.91-0.97) 0 (0-38) 8.04e-05
rs1357665 chr2:36174133 intergenic C vs. T All: C 15 108,990 0.433 (C) 0.317 (C) 0.94 (0.90-0.97) 0 (0-38) 6.79e-05
rs1357666 chr2:36174271 intergenic A vs. G All: C 15 108,990 0.442 (A) 0.317 (A) 0.94 (0.91-0.97) 0 (0-38) 8.65e-05
rs1510737 chr2:36175047 intergenic A vs. G All: C 15 108,990 0.433 (A) 0.317 (A) 0.94 (0.91-0.97) 0 (0-35) 7.17e-05
rs9973610 chr2:36249338 intergenic G vs. T All: C 15 108,990 0.233 (G) 0.242 (G) 0.92 (0.88-0.95) 0 (0-49) 2.90e-05
rs9973611 chr2:36249340 intergenic T vs. G All: C 15 108,990 - 0.242 (G) 1.09 (1.05-1.14) 0 (0-46) 1.79e-05
rs7573821 chr2:36250292 intergenic C vs. T All: C 15 108,990 0.258 (C) 0.267 (C) 0.91 (0.88-0.95) 0 (0-40) 2.03e-05
rs4670524 chr2:36250672 intergenic G vs. T All: C 15 108,990 0.275 (G) 0.242 (G) 0.92 (0.88-0.95) 0 (0-47) 2.00e-05
rs962378 chr2:36252307 intergenic G vs. T All: C 15 108,990 0.267 (G) 0.242 (G) 0.92 (0.88-0.95) 0 (0-46) 1.91e-05
rs996671 chr2:36253380 intergenic G vs. A All: C 15 108,990 0.275 (G) 0.25 (G) 0.92 (0.88-0.95) 0 (0-46) 1.66e-05
rs10495861 chr2:36254823 intergenic C vs. T All: C 15 108,990 0.267 (C) 0.267 (C) 0.92 (0.88-0.95) 0 (0-45) 1.86e-05
rs12987749 chr2:36255356 intergenic C vs. T All: C 15 108,990 0.267 (C) 0.275 (C) 0.92 (0.88-0.96) 0 (0-46) 2.16e-05
rs10201830 chr2:36259078 intergenic C vs. T All: C 15 108,990 0.25 (C) 0.267 (C) 0.92 (0.88-0.96) 0 (0-53) 5.57e-05
rs150832125 chr2:36901991 VIT [-21842bp] T vs. C All: C 14 105,041 - - 0.80 (0.72-0.89) 0 (0-45) 7.33e-05
rs141865127 chr2:36905821 VIT [-18012bp] A vs. G All: C 14 105,041 - - 0.81 (0.72-0.90) 0 (0-34) 1.56e-04
rs11709811 chr2:37092003 STRN A vs. G All: C 15 108,990 - - 1.10 (1.06-1.14) 0 (0-50) 6.65e-08
rs6491355 chr2:76933953 LRRTM4 [-40892bp] G vs. T All: C 15 108,990 - - 1.09 (1.05-1.14) 47 (3-71) 2.56e-05
rs12474195 chr2:95595941 intergenic C vs. T All: C 14 102,085 0.233 (C) 0.433 (C) 0.92 (0.88-0.96) 0 (0-31) 7.16e-05
rs7599246 chr2:95604114 intergenic G vs. A All: C 15 108,990 0.233 (G) 0.45 (G) 0.93 (0.90-0.97) 0 (0-47) 5.02e-04
rs62155152 chr2:102302650 MAP4K4 [-10662bp] C vs. T All: C 15 108,990 0.375 (C) 0.492 (C) 1.08 (1.04-1.11) 29 (0-62) 1.32e-05
rs6543086 chr2:102304852 MAP4K4 [-8460bp] G vs. A All: C 15 108,990 0.375 (G) 0.5 (G) 1.08 (1.04-1.11) 31 (0-63) 1.37e-05
rs7590913 chr2:102305953 MAP4K4 [-7359bp] G vs. A All: C 15 108,990 0.375 (G) 0.492 (A) 1.08 (1.04-1.11) 30 (0-62) 1.25e-05
rs6730672 chr2:102306462 MAP4K4 [-6850bp] C vs. T All: C 15 108,990 - - 0.93 (0.90-0.96) 30 (0-62) 1.54e-05
rs6745389 chr2:102306675 MAP4K4 [-6637bp] G vs. A All: C 15 108,990 0.375 (G) 0.492 (A) 1.08 (1.04-1.11) 30 (0-62) 1.22e-05
rs35917598 chr2:102312403 MAP4K4 [-909bp] C vs. T All: C 15 108,990 0.367 (C) 0.467 (C) 1.08 (1.04-1.11) 29 (0-62) 1.21e-05
rs35510684 chr2:102315321 MAP4K4 T vs. C All: C 15 108,990 0.383 (T) 0.467 (T) 1.08 (1.04-1.11) 29 (0-62) 1.10e-05
rs34451091 chr2:102319730 MAP4K4 G vs. T All: C 15 108,990 0.383 (G) 0.492 (G) 1.08 (1.04-1.11) 29 (0-62) 1.13e-05
rs11674694 chr2:102325324 MAP4K4 T vs. C All: C 15 108,990 0.383 (T) 0.483 (T) 1.08 (1.04-1.11) 28 (0-61) 1.40e-05
rs62155719 chr2:102330311 MAP4K4 G vs. A All: C 15 108,990 - - 0.93 (0.90-0.96) 29 (0-62) 1.18e-05
rs10432624 chr2:102331772 MAP4K4 T vs. C All: C 15 108,990 0.383 (T) 0.483 (T) 1.08 (1.04-1.11) 28 (0-61) 1.24e-05
rs6733355 chr2:102338377 MAP4K4 G vs. A All: C 15 108,990 0.383 (G) 0.458 (G) 1.08 (1.04-1.11) 27 (0-61) 1.16e-05
rs34979095 chr2:102344967 MAP4K4 C vs. T All: C 15 108,990 0.383 (C) 0.492 (C) 1.08 (1.04-1.12) 28 (0-62) 6.92e-06
rs4527225 chr2:102349515 MAP4K4 G vs. T All: C 15 108,990 0.383 (G) 0.5 (G) 1.08 (1.04-1.11) 22 (0-58) 1.11e-05
rs7569049 chr2:102353345 MAP4K4 G vs. T All: C 15 108,990 0.375 (G) 0.467 (G) 1.07 (1.04-1.11) 29 (0-62) 2.43e-05
rs62155733 chr2:102370764 MAP4K4 T vs. C All: C 15 108,990 0.383 (T) 0.5 (T) 1.08 (1.04-1.11) 25 (0-60) 1.47e-05
rs71415327 chr2:102377069 MAP4K4 G vs. A All: C 15 108,990 0.392 (G) 0.483 (G) 1.08 (1.04-1.11) 27 (0-61) 1.45e-05