Study: Nalls, 2014

Population Ethnicity Diagnosis Source # Cases (% women) # Controls (% women) AAO (sd) AAO range AAE (sd) AAE range Ctrl age (sd) Ctrl age range # Polymorphisms
USA (IPDGC-NIA) C UKPDSBB CL 937 (40%) 1896 (53%) 58 (13) - - - 63 (10) - 9,622

Polymorphisms in this population [-]

Polymorphism Location (hg19) Gene Allele contrast Ethnicity # Studies # Samples 1000G CEU 1000G CHB+JPT Meta OR (95%CI) I2 (95%CI) Meta P-value
rs823124 chr1:205726336 NUCKS1 [+6932bp] C vs. T All: C 15 108,990 0.0 (C) 0.175 (C) 0.80 (0.73-0.88) 1 (0-54) 1.67e-06
rs1626710 chr1:205727466 NUCKS1 [+8062bp] C vs. A All: C 15 108,990 0.008 (C) 0.158 (C) 0.85 (0.78-0.93) 2 (0-54) 2.20e-04
rs1772150 chr1:205727468 NUCKS1 [+8064bp] G vs. A All: C 15 108,990 0.008 (G) 0.183 (G) 0.85 (0.78-0.93) 1 (0-54) 2.27e-04
rs56276813 chr1:205730573 RAB7L1 [-6541bp] T vs. G All: C 15 108,990 0.3 (T) 0.425 (T) 0.93 (0.89-0.96) 37 (0-66) 3.36e-05
rs823145 chr1:205732512 RAB7L1 [-4602bp] C vs. T All: C 15 108,990 - - 1.26 (1.15-1.38) 0 (0-43) 6.81e-07
rs823147 chr1:205733138 RAB7L1 [-3976bp] A vs. G All: C 15 108,990 0.0 (A) 0.167 (A) 0.79 (0.72-0.87) 9 (0-46) 1.51e-06
rs1832775 chr1:205734032 RAB7L1 [-3082bp] T vs. C All: C 15 108,990 0.292 (T) 0.442 (T) 0.93 (0.89-0.96) 36 (0-66) 3.23e-05
rs823148 chr1:205735121 RAB7L1 [-1993bp] A vs. G All: C 15 108,990 0.017 (A) 0.167 (A) 0.79 (0.72-0.87) 13 (0-51) 1.24e-06
rs823149 chr1:205735229 RAB7L1 [-1885bp] A vs. C All: C 15 108,990 0.067 (A) 0.158 (A) 0.85 (0.80-0.91) 35 (0-65) 3.35e-07
rs823150 chr1:205735486 RAB7L1 [-1628bp] C vs. T All: C 15 108,990 0.008 (C) 0.158 (C) 0.80 (0.72-0.88) 0 (0-53) 4.87e-06
rs823151 chr1:205735517 RAB7L1 [-1597bp] C vs. T All: C 15 108,990 - - 1.26 (1.14-1.38) 2 (0-55) 1.69e-06
rs2014202 chr1:205735612 RAB7L1 [-1502bp] G vs. A All: C 15 108,990 - - 1.09 (1.05-1.13) 19 (0-56) 1.51e-06
rs7522056 chr1:205735891 RAB7L1 [-1223bp] A vs. G All: C 15 108,990 0.317 (A) 0.442 (A) 0.92 (0.89-0.95) 19 (0-56) 1.41e-06
rs823153 chr1:205736563 RAB7L1 [-551bp] A vs. G All: C 15 108,990 0.0 (A) 0.158 (A) 0.80 (0.73-0.87) 2 (0-55) 1.69e-06
rs1618936 chr1:205736663 RAB7L1 [-451bp] A vs. C All: C 15 108,990 - 0.15 (C) 1.27 (1.15-1.40) 10 (0-48) 2.03e-06
rs844005 chr1:205737450 RAB7L1 T vs. C All: C 15 108,990 0.0 (T) 0.167 (T) 0.80 (0.73-0.87) 3 (0-55) 1.68e-06
rs11557080 chr1:205737739 RAB7L1 G vs. A All: C 15 108,990 - - 0.87 (0.83-0.91) 42 (0-68) 7.64e-09
rs823132 chr1:205737764 RAB7L1 T vs. C All: C 15 108,990 - - 1.25 (1.14-1.37) 0 (0-53) 2.25e-06
rs823133 chr1:205737781 RAB7L1 C vs. T All: C 15 108,990 - - 1.24 (1.13-1.37) 0 (0-53) 4.22e-06
rs823135 chr1:205738166 RAB7L1 T vs. C All: C 15 108,990 0.008 (T) 0.167 (T) 0.80 (0.73-0.88) 0 (0-52) 9.39e-06
rs823136 chr1:205738251 RAB7L1 A vs. C All: C 15 108,990 - 0.167 (C) 1.26 (1.14-1.38) 3 (0-55) 1.76e-06
rs823138 chr1:205739192 RAB7L1 T vs. C All: C 15 108,990 0.0 (T) 0.167 (T) 0.80 (0.73-0.88) 2 (0-55) 2.11e-06
rs708723 chr1:205739266 RAB7L1 C vs. T All: C 15 108,990 0.442 (C) 0.392 (T) 0.89 (0.86-0.92) 56 (22-75) 1.38e-13
rs823139 chr1:205739396 RAB7L1 T vs. G All: C 15 108,990 0.125 (T) 0.158 (T) 0.90 (0.85-0.94) 36 (0-66) 1.38e-05
rs823140 chr1:205740403 RAB7L1 G vs. A All: C 15 108,990 - - 1.19 (1.10-1.29) 29 (0-62) 9.78e-06
rs823144 chr1:205744546 RAB7L1 C vs. A All: C 15 108,990 0.2 (C) 0.383 (A) 0.91 (0.87-0.94) 43 (0-69) 1.10e-07
rs1775151 chr1:205745684 RAB7L1 [+1096bp] C vs. T All: C 15 108,990 0.2 (C) 0.383 (T) 0.91 (0.87-0.94) 43 (0-69) 1.03e-07
rs1772153 chr1:205745782 RAB7L1 [+1194bp] T vs. C All: C 15 108,990 0.183 (T) 0.383 (C) 0.91 (0.87-0.94) 21 (0-57) 2.83e-07
rs1772154 chr1:205745932 RAB7L1 [+1344bp] T vs. C All: C 15 108,990 - - 1.10 (1.06-1.15) 21 (0-57) 2.67e-07
rs10900524 chr1:205748309 RAB7L1 [+3721bp] G vs. A All: C 15 108,990 0.183 (G) 0.383 (A) 0.91 (0.87-0.94) 20 (0-56) 2.47e-07
rs11394622 chr1:205749786 RAB7L1 [+5198bp] G vs. A All: C 15 108,990 - 0.15 (A) 1.31 (1.17-1.47) 2 (0-55) 2.44e-06
rs863725 chr1:205751196 RAB7L1 [+6608bp] C vs. T All: C 15 108,990 0.192 (C) - 0.90 (0.87-0.94) 40 (0-68) 6.45e-08
rs947211 chr1:205752665 SLC41A1 [-5556bp] A vs. G All: C 14 106,227 0.2 (A) 0.383 (G) 0.91 (0.87-0.94) 44 (0-70) 2.18e-07
rs1772156 chr1:205752894 SLC41A1 [-5327bp] T vs. C All: C 15 108,990 0.183 (T) 0.383 (C) 0.91 (0.87-0.94) 18 (0-55) 2.17e-07
rs885224 chr1:205753097 SLC41A1 [-5124bp] A vs. G All: C 15 108,990 0.208 (A) 0.383 (G) 0.90 (0.87-0.94) 41 (0-68) 7.64e-08
rs1775158 chr1:205753675 SLC41A1 [-4546bp] A vs. G All: C 15 108,990 - - 1.11 (1.07-1.15) 37 (0-66) 8.87e-08
rs1772157 chr1:205753808 SLC41A1 [-4413bp] C vs. T All: C 15 108,990 - - 1.10 (1.06-1.15) 17 (0-54) 2.27e-06
rs1775159 chr1:205753812 SLC41A1 [-4409bp] G vs. A All: C 15 108,990 - - 1.11 (1.06-1.15) 43 (0-69) 4.95e-07
rs1772158 chr1:205753820 SLC41A1 [-4401bp] C vs. T All: C 15 108,990 - - 1.11 (1.06-1.15) 42 (0-68) 5.43e-07
rs12565968 chr1:205755046 SLC41A1 [-3175bp] G vs. A All: C 15 108,990 0.192 (G) 0.383 (A) 0.91 (0.88-0.95) 34 (0-64) 2.53e-06
rs12565321 chr1:205755144 SLC41A1 [-3077bp] C vs. T All: C 15 108,990 - - 1.09 (1.05-1.13) 41 (0-68) 9.57e-06
rs12567894 chr1:205755151 SLC41A1 [-3070bp] T vs. C All: C 15 108,990 - - 1.09 (1.05-1.13) 42 (0-68) 1.22e-05
rs11240567 chr1:205755265 SLC41A1 [-2956bp] C vs. T All: C 15 108,990 - 0.35 (C) 1.10 (1.05-1.14) 31 (0-63) 2.41e-06
rs1775144 chr1:205756012 SLC41A1 [-2209bp] G vs. A All: C 15 108,990 0.0 (G) 0.158 (G) 0.79 (0.72-0.87) 4 (0-55) 9.61e-07
rs1775145 chr1:205756143 SLC41A1 [-2078bp] C vs. A All: C 15 108,990 0.208 (C) 0.392 (A) 0.91 (0.88-0.95) 51 (12-73) 8.66e-07
rs1775146 chr1:205756168 SLC41A1 [-2053bp] A vs. G All: C 15 108,990 0.2 (A) 0.392 (G) 0.92 (0.88-0.95) 33 (0-64) 3.57e-06
rs12740609 chr1:205756535 SLC41A1 [-1686bp] G vs. A All: C 15 108,990 - 0.167 (A) 1.29 (1.17-1.42) 24 (0-59) 3.95e-07
rs7536285 chr1:205757569 SLC41A1 [-652bp] T vs. C All: C 15 108,990 - - 1.09 (1.05-1.14) 35 (0-65) 2.89e-06
rs7513115 chr1:205757692 SLC41A1 [-529bp] A vs. G All: C 15 108,990 - - 1.09 (1.05-1.14) 34 (0-65) 2.77e-06
rs1775148 chr1:205757824 SLC41A1 [-397bp] T vs. C All: C 15 108,990 - - 1.10 (1.06-1.14) 0 (0-53) 7.16e-08