Study: Nalls, 2014

Population Ethnicity Diagnosis Source # Cases (% women) # Controls (% women) AAO (sd) AAO range AAE (sd) AAE range Ctrl age (sd) Ctrl age range # Polymorphisms
23andMe.v2 (USA, Europe) C self-reported clinical diagnosis O 3261 (39%) 29499 (42%) 64 (11) - - - 49 (15) - 9,752

Polymorphisms in this population [-]

Polymorphism Location (hg19) Gene Allele contrast Ethnicity # Studies # Samples 1000G CEU 1000G CHB+JPT Meta OR (95%CI) I2 (95%CI) Meta P-value
rs76518552 chr18:40690400 RIT2 G vs. A All: C 15 108,990 0.158 (G) 0.4 (G) 1.11 (1.06-1.17) 0 (0-41) 5.26e-05
rs79576710 chr18:40690410 RIT2 G vs. A All: C 15 108,990 0.167 (G) 0.408 (G) 1.11 (1.06-1.17) 0 (0-41) 5.13e-05
rs56384227 chr18:40690998 RIT2 G vs. A All: C 15 108,990 0.167 (G) 0.4 (G) 1.10 (1.05-1.15) 0 (0-37) 1.99e-05
rs3924792 chr18:40691463 RIT2 G vs. A All: C 15 108,990 0.158 (G) 0.4 (G) 1.10 (1.05-1.15) 0 (0-48) 6.70e-05
rs7235666 chr18:40695902 RIT2 [+245bp] C vs. G All: C 15 108,990 0.092 (C) 0.258 (C) 1.01 (0.96-1.07) 15 (0-52) 0.707
rs12455091 chr18:40699676 RIT2 [+4019bp] C vs. T All: C 15 108,990 0.1 (C) 0.267 (C) 1.01 (0.96-1.07) 14 (0-52) 0.712
rs10163682 chr18:40701725 RIT2 [+6068bp] T vs. C All: C 15 108,990 0.442 (T) 0.075 (T) 0.95 (0.92-0.98) 0 (0-53) 4.41e-04
rs6507515 chr18:40710324 RIT2 [+14667bp] A vs. G All: C 15 108,990 0.092 (A) 0.275 (A) 1.01 (0.96-1.06) 8 (0-45) 0.749
rs145444661 chr18:40717572 RIT2 [+21915bp] C vs. T All: C 11 95,804 - - 1.12 (0.92-1.36) 26 (0-63) 0.280
rs12605134 chr18:40766524 intergenic T vs. G All: C 15 108,990 0.325 (T) 0.433 (T) 1.09 (1.06-1.13) 6 (0-56) 3.99e-07
rs7241603 chr18:40797661 intergenic C vs. T All: C 15 108,990 0.425 (C) 0.375 (T) 1.06 (1.03-1.09) 0 (0-47) 5.36e-04
rs34332630 chr18:41167839 intergenic A vs. G All: C 15 108,990 0.233 (A) 0.058 (A) 1.07 (1.03-1.11) 0 (-) 0.002
rs4393648 chr18:41168311 intergenic A vs. G All: C 15 108,990 0.325 (A) 0.058 (A) 1.06 (1.02-1.10) 0 (-) 0.001
rs4890255 chr18:41178001 intergenic T vs. C All: C 15 108,990 0.325 (T) 0.067 (T) 1.06 (1.02-1.10) 0 (0-1) 0.001
rs9953470 chr18:41207659 intergenic T vs. C All: C 15 108,990 0.333 (T) 0.067 (T) 1.06 (1.02-1.10) 0 (-) 0.002
rs11082326 chr18:41213384 intergenic T vs. C All: C 15 108,990 0.392 (T) 0.342 (T) 1.06 (1.02-1.10) 0 (0-42) 0.001
rs58715341 chr18:44686124 IER3IP1 G vs. A All: C 15 108,990 0.108 (G) 0.167 (G) 1.10 (1.05-1.16) 0 (0-44) 8.29e-05
rs17711764 chr18:44710899 IER3IP1 [+8154bp] T vs. C All: C 15 108,990 0.108 (T) 0.15 (T) 1.10 (1.05-1.16) 0 (0-45) 8.08e-05
rs72909237 chr18:44711639 IER3IP1 [+8894bp] C vs. T All: C 15 108,990 0.1 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-45) 8.26e-05
rs72909238 chr18:44712036 IER3IP1 [+9291bp] G vs. A All: C 15 108,990 0.108 (G) 0.158 (G) 1.10 (1.05-1.16) 0 (0-45) 8.33e-05
rs72909244 chr18:44712130 IER3IP1 [+9385bp] C vs. T All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-45) 7.62e-05
rs10520715 chr18:44713275 IER3IP1 [+10530bp] C vs. A All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-45) 8.35e-05
rs72909248 chr18:44713737 IER3IP1 [+10992bp] C vs. A All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-46) 8.19e-05
rs11877644 chr18:44719611 IER3IP1 [+16866bp] C vs. T All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-45) 8.08e-05
rs10468987 chr18:44720241 IER3IP1 [+17496bp] G vs. T All: C 15 108,990 0.108 (G) 0.158 (G) 1.10 (1.05-1.16) 0 (0-45) 8.04e-05
rs11874862 chr18:44721752 IER3IP1 [+19007bp] C vs. T All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-46) 8.16e-05
rs11877745 chr18:44721892 IER3IP1 [+19147bp] A vs. C All: C 15 108,990 0.108 (A) 0.158 (A) 1.11 (1.05-1.16) 0 (0-48) 6.94e-05
rs11875558 chr18:44722179 IER3IP1 [+19434bp] C vs. T All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-47) 8.85e-05
rs60859098 chr18:44722979 IER3IP1 [+20234bp] G vs. A All: C 15 108,990 0.108 (G) 0.158 (G) 1.10 (1.05-1.16) 0 (0-46) 8.19e-05
rs72909271 chr18:44724846 SKOR2 [-21447bp] T vs. G All: C 15 108,990 0.1 (T) 0.158 (T) 1.10 (1.05-1.16) 0 (0-46) 8.43e-05
rs11082565 chr18:44725768 SKOR2 [-20525bp] A vs. G All: C 15 108,990 0.108 (A) 0.158 (A) 1.11 (1.05-1.17) 0 (0-42) 7.86e-05
rs12326980 chr18:44726171 SKOR2 [-20122bp] G vs. A All: C 15 108,990 0.108 (G) 0.158 (G) 1.11 (1.05-1.16) 0 (0-46) 6.04e-05
rs12327400 chr18:44727998 SKOR2 [-18295bp] A vs. G All: C 15 108,990 0.108 (A) 0.158 (A) 1.11 (1.05-1.16) 0 (0-45) 5.07e-05
rs17784795 chr18:44728744 SKOR2 [-17549bp] C vs. T All: C 15 108,990 0.108 (C) 0.158 (C) 1.10 (1.05-1.16) 0 (0-47) 9.88e-05
rs11873315 chr18:44730823 SKOR2 [-15470bp] G vs. A All: C 15 108,990 0.108 (G) 0.158 (G) 1.11 (1.05-1.16) 0 (0-47) 6.52e-05
rs11082566 chr18:44731076 SKOR2 [-15217bp] T vs. C All: C 15 108,990 0.117 (T) 0.158 (T) 1.11 (1.05-1.16) 0 (0-47) 5.20e-05
rs17784867 chr18:44732687 SKOR2 [-13606bp] C vs. T All: C 15 108,990 0.108 (C) 0.158 (C) 1.11 (1.05-1.16) 0 (0-47) 6.63e-05
rs76984555 chr18:46367492 CTIF A vs. G All: C 14 105,041 0.033 (A) 0.417 (A) 0.86 (0.79-0.93) 0 (0-46) 8.73e-05
rs16950052 chr18:46382353 CTIF C vs. T All: C 14 105,041 0.058 (C) 0.425 (C) 0.87 (0.81-0.93) 0 (0-51) 7.45e-05
rs141070920 chr18:46389511 CTIF G vs. A All: C 14 105,041 - - 1.20 (1.10-1.31) 14 (0-53) 4.60e-05
rs75368394 chr18:50301737 DCC C vs. A All: C 15 108,990 0.108 (C) - 1.13 (1.07-1.20) 4 (0-56) 2.57e-05
rs113902371 chr18:50301765 DCC C vs. T All: C 15 108,990 0.108 (C) - 1.13 (1.07-1.20) 4 (0-56) 2.59e-05
rs9954223 chr18:50301788 DCC G vs. A All: C 15 108,990 0.108 (G) - 1.11 (1.06-1.17) 0 (0-51) 6.68e-05
rs9954366 chr18:50301832 DCC T vs. C All: C 15 108,990 0.108 (T) 0.033 (T) 1.11 (1.06-1.17) 0 (0-50) 7.27e-05
rs9954387 chr18:50301888 DCC T vs. C All: C 15 108,990 0.108 (T) - 1.11 (1.06-1.17) 0 (0-51) 7.27e-05
rs9956954 chr18:50302147 DCC T vs. C All: C 15 108,990 0.108 (T) - 1.11 (1.06-1.17) 0 (0-49) 6.88e-05
rs9946240 chr18:50302221 DCC C vs. T All: C 15 108,990 0.108 (C) 0.033 (C) 1.11 (1.05-1.17) 0 (0-51) 7.47e-05
rs9957066 chr18:50302280 DCC T vs. C All: C 15 108,990 0.108 (T) 0.033 (T) 1.11 (1.05-1.17) 0 (0-51) 7.42e-05
rs28720976 chr18:50302448 DCC T vs. C All: C 15 108,990 0.108 (T) 0.033 (T) 1.11 (1.05-1.17) 0 (0-51) 7.76e-05
rs28710315 chr18:50302476 DCC T vs. C All: C 15 108,990 0.108 (T) 0.033 (T) 1.11 (1.05-1.17) 0 (0-50) 8.23e-05