Study: Nalls, 2014

Population Ethnicity Diagnosis Source # Cases (% women) # Controls (% women) AAO (sd) AAO range AAE (sd) AAE range Ctrl age (sd) Ctrl age range # Polymorphisms
23andMe.v3 (USA, Europe) C self-reported clinical diagnosis O 866 (39%) 32538 (40%) 64 (11) - - - 44 (16) - 9,852

Polymorphisms in this population [-]

Polymorphism Location (hg19) Gene Allele contrast Ethnicity # Studies # Samples 1000G CEU 1000G CHB+JPT Meta OR (95%CI) I2 (95%CI) Meta P-value
rs8128471 chr21:44357289 MIR5692B [-13749bp] T vs. C All: C 15 108,990 - - 1.08 (1.05-1.12) 9 (0-46) 9.12e-06
rs2187248 chr21:44357419 MIR5692B [-13619bp] G vs. T All: C 15 108,990 - - 1.08 (1.05-1.12) 0 (0-51) 6.78e-06
rs7282181 chr21:44357886 MIR5692B [-13152bp] G vs. A All: C 15 108,990 0.433 (G) 0.292 (G) 1.08 (1.04-1.12) 30 (0-62) 1.16e-05
rs452142 chr21:44412809 PKNOX1 G vs. A All: C 15 108,990 0.258 (G) - 1.10 (1.05-1.14) 1 (0-54) 5.04e-06
rs35879780 chr21:44413457 PKNOX1 A vs. G All: C 15 108,990 0.142 (A) - 1.11 (1.06-1.16) 0 (0-48) 4.84e-05
rs234690 chr21:44431358 PKNOX1 T vs. G All: C 15 108,990 - - 0.94 (0.90-0.97) 6 (0-57) 3.94e-04
rs234731 chr21:44449389 PKNOX1 A vs. G All: C 15 108,990 0.325 (A) 0.033 (A) 1.08 (1.04-1.11) 0 (0-51) 3.82e-05
rs418639 chr21:44468843 CBS [-4458bp] G vs. A All: C 15 108,990 0.258 (G) - 1.09 (1.05-1.13) 0 (0-44) 2.62e-05
rs71328211 chr22:17858431 CECR2 C vs. T All: C 9 88,686 - - 1.35 (1.16-1.56) 32 (0-69) 7.03e-05
rs5746359 chr22:17860048 CECR2 T vs. C All: C 14 108,544 0.075 (T) 0.158 (T) 0.84 (0.76-0.92) 9 (0-47) 2.31e-04
rs62235900 chr22:31170608 OSBP2 T vs. C All: C 14 103,470 0.017 (T) - 1.03 (0.91-1.18) 51 (9-73) 0.622
rs136222 chr22:31219913 OSBP2 G vs. A All: C 7 83,185 - - 0.62 (0.37-1.05) 26 (0-68) 0.077
rs2267424 chr22:41489526 EP300 C vs. A All: C 15 108,990 0.3 (C) 0.15 (C) 1.07 (1.03-1.10) 4 (0-56) 9.45e-05
rs5751040 chr22:41491276 EP300 C vs. T All: C 15 108,990 - - 0.94 (0.91-0.97) 3 (0-55) 9.65e-05
rs9607772 chr22:41492653 EP300 G vs. A All: C 15 108,990 0.308 (G) 0.108 (G) 1.07 (1.03-1.10) 5 (0-56) 8.21e-05
rs738628 chr22:41493474 EP300 C vs. T All: C 15 108,990 0.333 (C) 0.175 (C) 1.07 (1.03-1.10) 4 (0-56) 8.63e-05
rs2899344 chr22:41494468 EP300 T vs. C All: C 15 108,990 - - 0.94 (0.91-0.97) 5 (0-56) 8.48e-05
rs5751042 chr22:41495329 EP300 G vs. A All: C 15 108,990 0.292 (G) - 1.07 (1.03-1.10) 4 (0-56) 8.32e-05
rs5758228 chr22:41497234 EP300 G vs. A All: C 15 108,990 - - 0.94 (0.91-0.97) 5 (0-56) 7.60e-05
rs2024717 chr22:41497785 EP300 C vs. T All: C 15 108,990 0.3 (C) 0.35 (C) 1.07 (1.03-1.10) 3 (0-55) 7.70e-05
rs4822004 chr22:41502825 EP300 T vs. G All: C 15 108,990 0.292 (T) 0.333 (T) 1.07 (1.03-1.10) 6 (0-57) 7.61e-05
rs9611497 chr22:41507400 EP300 A vs. G All: C 15 108,990 0.292 (A) 0.142 (A) 1.07 (1.03-1.10) 4 (0-56) 7.42e-05
rs5995996 chr22:41508393 EP300 T vs. G All: C 15 108,990 0.317 (T) - 1.07 (1.03-1.10) 6 (0-56) 7.59e-05
rs738629 chr22:41510179 EP300 G vs. T All: C 15 108,990 0.35 (G) 0.183 (G) 1.07 (1.03-1.10) 3 (0-55) 9.81e-05
rs738630 chr22:41511171 EP300 T vs. C All: C 15 108,990 0.292 (T) 0.133 (T) 1.07 (1.03-1.10) 6 (0-57) 8.14e-05
rs738631 chr22:41511176 EP300 G vs. A All: C 15 108,990 0.292 (G) 0.133 (G) 1.07 (1.03-1.10) 6 (0-57) 8.10e-05
rs2064558 chr22:41512609 EP300 G vs. A All: C 15 108,990 0.292 (G) 0.142 (G) 1.07 (1.03-1.10) 5 (0-56) 7.77e-05
rs2144342 chr22:41513094 EP300 G vs. T All: C 15 108,990 0.3 (G) 0.133 (G) 1.07 (1.03-1.10) 6 (0-57) 7.69e-05
rs4822005 chr22:41514155 EP300 G vs. A All: C 15 108,990 0.3 (G) 0.167 (G) 1.07 (1.03-1.10) 9 (0-46) 6.24e-05
rs5758237 chr22:41515744 EP300 T vs. G All: C 15 108,990 0.3 (T) 0.133 (T) 1.07 (1.03-1.10) 6 (0-57) 7.54e-05
rs5758238 chr22:41519308 EP300 G vs. A All: C 15 108,990 0.3 (G) 0.167 (G) 1.07 (1.03-1.10) 6 (0-56) 7.78e-05
rs5758240 chr22:41521717 EP300 T vs. C All: C 15 108,990 0.292 (T) 0.142 (T) 1.07 (1.03-1.10) 6 (0-56) 7.13e-05
rs738632 chr22:41523937 EP300 A vs. G All: C 15 108,990 0.292 (A) 0.342 (A) 1.07 (1.03-1.10) 3 (0-55) 6.72e-05
rs73176607 chr22:41528323 EP300 A vs. C All: C 15 108,990 - - 0.94 (0.91-0.97) 5 (0-56) 7.15e-05
rs4822007 chr22:41532934 EP300 C vs. T All: C 15 108,990 - - 0.94 (0.91-0.97) 5 (0-56) 7.09e-05
rs4822010 chr22:41539424 EP300 T vs. C All: C 15 108,990 0.308 (T) - 1.07 (1.03-1.11) 9 (0-46) 6.98e-05
rs1569858 chr22:41541024 EP300 A vs. G All: C 15 108,990 0.3 (A) 0.142 (A) 1.07 (1.03-1.10) 3 (0-55) 7.14e-05
rs6002268 chr22:41549009 EP300 T vs. C All: C 15 108,990 0.317 (T) - 1.07 (1.04-1.10) 5 (0-56) 5.70e-05
rs4820431 chr22:41549921 EP300 A vs. C All: C 15 108,990 0.292 (A) 0.092 (A) 1.07 (1.04-1.10) 5 (0-56) 5.83e-05
rs4822011 chr22:41550954 EP300 C vs. T All: C 15 108,990 0.3 (C) 0.167 (C) 1.07 (1.04-1.10) 5 (0-56) 5.82e-05
rs1033611 chr22:41558232 EP300 A vs. G All: C 15 108,990 0.292 (A) 0.308 (A) 1.07 (1.04-1.11) 6 (0-56) 5.03e-05
rs9607779 chr22:41566823 EP300 G vs. A All: C 15 108,990 - - 0.94 (0.91-0.97) 6 (0-56) 4.63e-05
rs5751060 chr22:41567722 EP300 T vs. G All: C 15 108,990 - - 0.94 (0.91-0.97) 5 (0-56) 6.16e-05
rs2076577 chr22:41568480 EP300 T vs. C All: C 15 108,990 0.3 (T) 0.317 (T) 1.07 (1.04-1.11) 5 (0-56) 5.10e-05
rs2076581 chr22:41570071 EP300 C vs. T All: C 15 108,990 - - 0.94 (0.91-0.97) 1 (0-54) 5.13e-05
rs136394 chr22:41578065 EP300 [+1984bp] A vs. G All: C 15 108,990 0.308 (A) 0.092 (A) 1.07 (1.03-1.10) 5 (0-56) 7.41e-05
rs4408817 chr22:41580713 EP300 [+4632bp] C vs. T All: C 15 108,990 0.3 (C) 0.35 (C) 1.07 (1.03-1.10) 5 (0-56) 7.19e-05
rs2038208 chr22:41585793 EP300 [+9712bp] G vs. T All: C 15 108,990 - - 0.94 (0.91-0.97) 8 (0-46) 7.16e-05
rs4822016 chr22:41586320 EP300 [+10239bp] T vs. C All: C 15 108,990 - - 0.94 (0.91-0.97) 9 (0-47) 9.15e-05
rs5758257 chr22:41593636 L3MBTL2 [-7573bp] G vs. A All: C 15 108,990 0.292 (G) - 1.07 (1.03-1.10) 8 (0-45) 8.41e-05