Study: Nalls, 2014

Population	Ethnicity	Diagnosis	Source	# Cases (% women)	# Controls (% women)	AAO (sd)	AAO range	AAE (sd)	AAE range	Ctrl age (sd)	Ctrl age range	# Polymorphisms
23andMe.v2 (USA, Europe)	C	self-reported clinical diagnosis	O	3261 (39%)	29499 (42%)	64 (11)	-	-	-	49 (15)	-	9,752
23andMe.v3 (USA, Europe)	C	self-reported clinical diagnosis	O	866 (39%)	32538 (40%)	64 (11)	-	-	-	44 (16)	-	9,852
France (IPDGC)	C	UKPDSBB	CL	985 (41%)	1984 (33%)	49 (13)	-	-	-	74 (5)	-	9,821
France (NeuroX)	C	not provided	CL	553	474	-	-	-	-	-	-	27
Germany (IPDGC)	C	UKPDSBB	CL, PO	667 (40%)	937 (48%)	56 (12)	-	-	-	47 (12)	-	9,646
Germany (NeuroX)	C	not provided	CL	1,044	871	-	-	-	-	-	-	27
Greece (NeuroX)	C	not provided	CL	944	877	-	-	-	-	-	-	27
Iceland (IPDGC-deCODE)	C	UKPDSBB	CL	604 (48%)	4916 (57%)	62 (12)	-	-	-	80 (8)	-	9,406
Iceland (CHARGE-AGES-RS)	C	ICD codes, medication	PO	146 (55%)	5609 (59%)	75 (8)	-	-	-	69 (9)	-	8,205
Netherlands (IPDGC)	C	UKPDSBB	CL, PO	744 (36%)	2019 (64%)	56 (12)	-	-	-	56 (6)	-	9,595
Netherlands (NeuroX)	C	not provided	CL	97	247	-	-	-	-	-	-	27
UK (IPDGC)	C	UKPDSBB	CL, PO	1705 (43%)	5200 (50%)	64 (12)	-	-	-	53 (0)	-	9,673
UK (NeuroX)	C	not provided	CL	405	547	-	-	-	-	-	-	27
USA (IPDGC-NIA)	C	UKPDSBB	CL	937 (40%)	1896 (53%)	58 (13)	-	-	-	63 (10)	-	9,622
USA (Ashkenazi)	C	UKPDSBB	CL	268 (33%)	178 (57%)	60 (12)	-	-	-	70 (9)	-	9,631
USA (HIHG)	C	UKPDSBB	CL	574 (37%)	619 (65%)	57 (12)	-	-	-	69 (10)	-	9,723
USA (NGRC)	C	UKPDSBB	CL	1956 (33%)	1982 (61%)	59 (12)	-	-	-	70 (14)	-	9,938
USA (PROGENI-GenePD)	C	UKPDSBB	CL	828 (40%)	852 (60%)	62 (11)	-	-	-	55 (13)	-	9,762
USA (CHARGE-CHS)	C	self-report, ICD-9, medications	PO	107 (45%)	3164 (61%)	73 (5)	-	-	-	72 (5)	-	9,655
USA (CHARGE-FHS)	C	UKPDSBB	PO	60 (42%)	3889 (55%)	76 (11)	-	-	-	64 (12)	-	9,223
USA (NeuroX)	C	not provided	CL	2,407	2,782	-	-	-	-	-	-	27

Polymorphism	Location (hg19)	Gene	Allele contrast	Ethnicity	# Studies	# Samples	1000G CEU	1000G CHB+JPT	Meta OR (95%CI)	I2 (95%CI)	Meta P-value
rs1775148	chr1:205757824	SLC41A1 [-397bp]	T vs. C	All: C	15	108,990	-	-	1.10 (1.06-1.14)	0 (0-53)	7.16e-08
rs1341249	chr1:205759876	SLC41A1	T vs. C	All: C	15	108,990	0.167 (T)	0.392 (C)	0.91 (0.87-0.95)	3 (0-55)	1.01e-05
rs708726	chr1:205762139	SLC41A1	T vs. G	All: C	15	108,990	0.192 (T)	0.4 (G)	0.91 (0.88-0.95)	21 (0-57)	1.34e-06
rs823155	chr1:205762946	SLC41A1	T vs. C	All: C	15	108,990	0.192 (T)	0.392 (C)	0.91 (0.88-0.95)	22 (0-58)	1.34e-06
rs823156	chr1:205764640	SLC41A1	G vs. A	All: C	15	108,990	0.142 (G)	0.258 (G)	0.91 (0.87-0.95)	29 (0-62)	8.37e-06
rs823065	chr1:205771061	SLC41A1	T vs. G	All: C	15	108,990	0.05 (T)	0.258 (T)	0.86 (0.80-0.92)	0 (0-38)	1.03e-05
rs823066	chr1:205771173	SLC41A1	A vs. G	All: C	15	108,990	0.05 (A)	0.258 (A)	0.86 (0.80-0.92)	0 (0-39)	1.16e-05
rs823067	chr1:205771704	SLC41A1	C vs. T	All: C	15	108,990	-	-	1.16 (1.08-1.24)	0 (0-44)	2.81e-05
rs823068	chr1:205771720	SLC41A1	C vs. T	All: C	15	108,990	-	-	1.16 (1.09-1.25)	0 (0-36)	1.81e-05
rs823069	chr1:205771801	SLC41A1	A vs. G	All: C	15	108,990	-	-	1.10 (1.06-1.15)	44 (0-70)	4.53e-06
rs823070	chr1:205772370	SLC41A1	T vs. C	All: C	15	108,990	0.05 (T)	0.258 (T)	0.86 (0.80-0.92)	0 (0-40)	1.24e-05
rs823071	chr1:205773379	SLC41A1	G vs. T	All: C	15	108,990	0.05 (G)	0.258 (G)	0.86 (0.80-0.92)	0 (0-35)	9.96e-06
rs708729	chr1:205773461	SLC41A1	C vs. T	All: C	15	108,990	0.15 (C)	0.258 (C)	0.91 (0.87-0.94)	47 (3-71)	3.00e-06
rs823072	chr1:205773652	SLC41A1	C vs. T	All: C	15	108,990	0.167 (C)	0.258 (C)	0.91 (0.88-0.95)	46 (1-70)	7.44e-06
rs823073	chr1:205774156	SLC41A1	T vs. C	All: C	15	108,990	0.042 (T)	0.258 (T)	0.85 (0.79-0.92)	0 (0-43)	1.31e-05
rs823076	chr1:205775810	SLC41A1	T vs. C	All: C	15	108,990	0.05 (T)	0.267 (T)	0.85 (0.79-0.92)	0 (0-21)	6.98e-05
rs823077	chr1:205776109	SLC41A1	T vs. C	All: C	15	108,990	0.05 (T)	0.258 (T)	0.86 (0.80-0.92)	0 (0-40)	1.42e-05
rs823078	chr1:205776458	SLC41A1	T vs. C	All: C	15	108,990	0.058 (T)	0.258 (T)	0.86 (0.80-0.92)	0 (0-40)	1.42e-05
rs823079	chr1:205777159	SLC41A1	C vs. T	All: C	15	108,990	-	-	1.17 (1.09-1.25)	0 (0-40)	1.42e-05
rs708730	chr1:205777780	SLC41A1	G vs. A	All: C	15	108,990	0.117 (G)	0.258 (G)	0.91 (0.87-0.95)	55 (20-75)	9.00e-06
rs844004	chr1:205792680	PM20D1 [-4470bp]	T vs. C	All: C	15	108,990	0.05 (T)	0.258 (T)	0.87 (0.81-0.93)	0 (0-45)	8.80e-05
rs823085	chr1:205798033	PM20D1	G vs. A	All: C	15	108,990	0.058 (G)	0.258 (G)	0.87 (0.81-0.93)	0 (0-38)	6.10e-05
rs11240572	chr1:205808013	PM20D1	C vs. A	All: C	15	108,990	-	0.208 (A)	1.22 (1.12-1.34)	11 (0-49)	1.75e-05
rs7355095	chr1:221829733	DUSP10 [-45033bp]	C vs. A	All: C	15	108,990	0.108 (C)	0.183 (C)	0.89 (0.84-0.94)	0 (0-28)	5.36e-05
rs7355053	chr1:221829784	DUSP10 [-44982bp]	A vs. C	All: C	15	108,990	0.108 (A)	0.192 (A)	0.89 (0.85-0.95)	0 (0-26)	6.77e-05
rs12039242	chr1:226905927	ITPKB	G vs. A	All: C	15	108,990	-	-	0.90 (0.86-0.94)	3 (0-55)	1.28e-05
rs708769	chr1:226906961	ITPKB	C vs. T	All: C	15	108,990	0.408 (C)	0.392 (C)	0.93 (0.90-0.96)	5 (0-56)	3.10e-06
rs1289274	chr1:226909364	ITPKB	T vs. C	All: C	15	108,990	-	-	1.08 (1.04-1.11)	0 (0-54)	1.01e-05
rs3768408	chr1:226910340	ITPKB	T vs. C	All: C	15	108,990	0.15 (T)	0.417 (T)	1.11 (1.06-1.16)	3 (0-55)	1.46e-05
rs708770	chr1:226912135	ITPKB	A vs. G	All: C	15	108,990	0.408 (A)	0.392 (A)	0.93 (0.90-0.96)	11 (0-49)	3.90e-06
rs3768411	chr1:226912196	ITPKB	A vs. C	All: C	15	108,990	0.15 (A)	0.308 (A)	1.11 (1.06-1.16)	5 (0-56)	1.72e-05
rs708772	chr1:226912891	ITPKB	C vs. T	All: C	15	108,990	0.408 (C)	0.392 (C)	0.93 (0.90-0.96)	12 (0-50)	4.80e-06
rs4653767	chr1:226916078	ITPKB	C vs. T	All: C	15	108,990	0.283 (C)	0.325 (C)	0.92 (0.89-0.95)	10 (0-47)	3.43e-06
rs10495249	chr1:226919119	ITPKB	G vs. A	All: C	15	108,990	0.283 (G)	0.325 (G)	0.92 (0.89-0.95)	5 (0-56)	3.68e-06
rs708773	chr1:226920730	ITPKB	C vs. T	All: C	15	108,990	0.283 (C)	0.325 (C)	0.92 (0.89-0.95)	6 (0-57)	4.29e-06
rs708775	chr1:226923264	ITPKB	A vs. G	All: C	15	108,990	0.283 (A)	0.325 (A)	0.92 (0.89-0.95)	5 (0-56)	4.30e-06
rs7525200	chr1:232156584	DISC1	C vs. T	All: C	15	108,990	0.033 (C)	0.05 (C)	1.13 (1.00-1.28)	18 (0-55)	0.057
rs78071873	chr1:232158581	DISC1	T vs. C	All: C	15	108,990	0.033 (T)	-	1.11 (0.99-1.25)	11 (0-49)	0.075
rs77545015	chr1:232160108	DISC1	G vs. C	All: C	15	108,990	0.033 (G)	0.05 (G)	1.10 (0.98-1.24)	11 (0-48)	0.098
rs75978425	chr1:232161710	DISC1	G vs. C	All: C	15	108,990	0.05 (G)	0.05 (G)	1.07 (0.97-1.18)	0 (0-9)	0.172
rs77016139	chr1:232161711	DISC1	T vs. A	All: C	15	108,990	0.05 (T)	0.05 (T)	1.07 (0.97-1.18)	0 (0-8)	0.174
rs6703676	chr1:232344958	intergenic	T vs. C	All: C	15	108,990	0.425 (T)	0.175 (C)	1.05 (1.02-1.08)	25 (0-60)	0.003
rs7411832	chr1:232349350	intergenic	C vs. A	All: C	15	108,990	0.45 (C)	0.242 (A)	1.05 (1.02-1.08)	25 (0-60)	0.003
rs7415668	chr1:232349548	intergenic	G vs. A	All: C	15	108,990	0.45 (G)	0.242 (A)	1.05 (1.02-1.08)	25 (0-60)	0.003
rs7412349	chr1:232349765	intergenic	C vs. T	All: C	15	108,990	0.45 (C)	0.242 (T)	1.05 (1.02-1.08)	25 (0-60)	0.003
rs10797564	chr1:232350987	intergenic	G vs. A	All: C	15	108,990	0.45 (G)	0.242 (A)	1.05 (1.02-1.08)	24 (0-59)	0.003
rs12075606	chr1:232363452	intergenic	A vs. T	All: C	15	108,990	0.092 (A)	0.058 (A)	0.92 (0.87-0.97)	20 (0-56)	0.001
rs28888187	chr1:232366668	intergenic	A vs. C	All: C	14	105,041	-	-	1.13 (1.05-1.22)	9 (0-47)	0.001
rs35186494	chr1:232657647	SIPA1L2	C vs. T	All: C	15	108,990	0.108 (C)	0.117 (C)	1.14 (1.09-1.19)	0 (0-47)	2.03e-08
rs2357070	chr1:232658363	SIPA1L2	A vs. G	All: C	15	108,990	0.183 (A)	0.333 (G)	1.09 (1.05-1.14)	29 (0-62)	8.01e-06

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Study: Nalls, 2014

Polymorphisms in this study [-][+]